Molecular Genetic Pathology Fellowship

Molecular Genetic Pathology Fellowship

 We are pleased to announce our ACGME-approved Molecular Genetic Pathology Fellowship. The  Duke Cytogenetics and Duke Molecular Diagnostics laboratories share a common laboratory space on the main campus of Duke Hospital, Fellows are exposed to blocks of constitutional/germline testing, hematologic malignancy testing, and solid tumor testing during which the intent is to learn how both cytogenetic and molecular techniques are employed to answer clinical questions. The fellow will gain experience in a wide range of laboratory techniques, including:

  • Chromosome analysis (prenatal, postnatal, bone marrow)
  • FISH (constitutional, hematologic malignancy, solid tumor)
  • Microarray analysis
  • NGS and Sanger sequencing (hematologic malignancy, solid tumor, and constitutional)
  • Methylation assays (PWS/AS, MLH1 promoter)
  • Carrier screening (cystic fibrosis, hemochromatosis, SMA, Fragile X, etc.)
  • qPCR (BCR/ABL1 quantification, somatic mutation detection)
  • Somatic mutations and aberrations (MSI, T– and B–cell clonality, IGH somatic mutation, etc.)
  • Bone marrow engraftment analysis via STR profiling

Opportunities exist for rotations within various medical genetics clinics including general medical genetics clinic, Down syndrome clinic, exome clinic, metabolic clinic, and prenatal and hereditary cancer clinics. There are opportunities to visit other Duke laboratories such as flow cytometry, microbiology, and image cytometry. In addition to gaining experience in the fields of cytogenetics and molecular genetics, fellows will participate in new test development and validation, as well as the ongoing quality improvement initiatives. Fellows will also gain experience in the laboratory inspection process, and are expected to become familiar with the requirements of regulatory and licensing agencies such as CAP and CLIA. Laboratory fellows may also attend national conferences and participate in clinical research.

Program Overview

Positions offered per year: One
Program duration: 1 year
Accrediting body: Accreditation Council for Graduate Medical Education (ACGME)

How to apply

To apply, please submit your CV, personal statement, and three letters of recommendation to Program Director Dr. Jadee Neff

Application should be submitted between September and October of the prior to the desired start date, which is typically 7/1.

All applications are considered without regard to race, religion, gender, or national origin.

Stipends

Commensurate with the year of postgraduate training.

Program Director

Jadee Neff, MD, PhD, FCAP
Hematopathology and Molecular Genetic Pathology
Department of Pathology
Box 3712 DUMC
Durham, NC 27710
Email

Program Coordinator

Debra Andersen
Program Coordinator
Department of Pathology
Box 3712 DUMC
Durham, NC 27710
919.684.2070
Email