SECONDARY FACULTY LABS

Secondary Faculty Labs

 

 
Hidden Staff/Faculty: 
Alman; Gurpreet Baht; Gayathri Devi, PhD; Filiano; Gunn; Kraus; Liton: Patz; Lyerly; Malek; McNulty; Sempowski,
Dr. Gurpreet Baht- Lab

Baht Lab

The Baht Lab focuses on understanding the processes involved in bone fracture healing. Current efforts in the laboratory are concentrated on understanding the role of cellular metabolism in age-dependent decrease in tissue regeneration and cellular differentiation.

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Bigner Lab

My research involves the investigation of the causes, mechanism of transformation and altered growth control, and development of new methods of therapy for primary brain tumors and those metastasizing to the CNS and its protective coverings.

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Devi Gayathri

Devi Lab

My research focus is on fundamental aspects of programmed cell death signaling and its applications in translational medicine. I have a long-standing interest and expertise in studying the Inhibitor of Apoptosis family of proteins (IAP), in particular in vitro and in vivo modeling of the escape of tumor cells from apoptosis and genomics based therapeutic strategies.

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Dr. Filiano

Filiano Lab

Our lab is interested in understanding the complex interactions between the immune system and nervous system. We are investigating how cytokines, and other immune-cell derived molecules, can regulate neural circuits and how an imbalance in these molecules might affect the brain in autism spectrum and other related disorders. We are also investigating how cord-blood derived cells and products can be used to promote healthy brain function and alleviate behavioral dysfunction in these devastating neurological conditions.

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Gunn Lab

The Gunn lab specializes in the translation of immunology to human disease.  Current lab projects include: using advanced flow cytometric analysis to identify and characterize inflammatory cell populations in models of human disease; the development of a novel cellular vaccine strategy for the treatment of cancer; the development of a novel pharmacologic treatment for Acute Lung Injury; and the use of single chain antibody phage display technology to generate antibodies for use in point-of-care assays for the diagnosis of infections.

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Kraus Lab

The laboratory of Dr. Virginia Byers Kraus focuses on the pathogenesis of osteoarthritis and discovery, validation and qualification of biomarkers to facilitate clinical trials and clinical practice in the treatment of individuals with this, the oldest known and most prevalent of the world’s diseases.

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Liton Lab

Dr. Liton’s lab interests are focused on investigating a role of autophagy lysosomal pathway in ocular physiology and pathophysiology.  Current efforts in her laboratory are directed at investigating a potential role of impaired autophagy in ocular hypertension and glaucoma.

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Lyerly Lab

Our primary laboratory research focus is on breast cancer and cancer immunotherapy research.

The Center for Applied Therapeutics encompasses a broad array of research activities involved in the development, preclinical testing, and clinical testing of novel therapies targeting cancer or precancerous conditions. The Center consists of over 30 individuals ranging from senior scientists to post-doctoral fellows, which serves as a robust environment for research activity in a broad array of applied therapeutics.

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Malek Lab

Age-related macular degeneration (AMD) is the leading cause of vision loss in the elderly. Basic and translational aspects of the research performed in the Malek lab include identifying signaling pathways that are either altered in AMD or pathways that may be targeted to improve and enhance cellular function of ocular cells affected in the disease.

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McNulty Lab

The McNulty Lab is working to develop strategies to prevent osteoarthritis and to promote tissue repair and regeneration following joint injury. We are working to understand the pathways that are activated by normal and injurious mechanical loading of cartilage and meniscus and how these mechanotransduction pathways are altered during aging, injury, and tissue degeneration. A greater understanding of alterations in mechanosensitive signaling mechanisms with aging and injury will likely reveal potential targets to promote tissue repair and prevent tissue degeneration and osteoarthritis development.

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Susan Murphy, PhD

Murphy Lab

The Murphy lab is focused on gynecologic malignancies, including ovarian and cervical cancers, with work on etiology and biology, epigenetic alterations in malignancy, cancer stem cells and how to target residual cancer cells during disease remission to prevent recurrence.  We also study the establishment and maintenance of DNA methylation in humans and how epigenetic deregulation in early life is associated with neurodevelopment and later disease. 

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Patz Lab

The work in our laboratory focuses on translational issues related to early cancer detection and metastasis. Current projects are on discovery of lung cancer biomarkers and exploration of the host immune response to cancer.

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Sempowski Lab

Dr. Sempowski’s laboratory focuses on thymic aging, immunosenescence and multiplex biomarker analysis.  He is also the Director of the Regional Biocontainment Laboratory at Duke.  This ~12,000sqft BSL2/3 facility at Duke was built with funding from the NIH to support basic research necessary to develop drugs, diagnostics, and vaccines for emerging/reemerging infections and biodefense.

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