Neuropathology

Neuropathology is the subspecialty of Pathology and Neurosciences with special expertise in diseases of the nervous system and its coverings.

Neuropathologists study portions of brain tissues removed at surgery (biopsies) and brains removed at autopsy for diagnosis. The tissue is examined grossly and microscopically for signs of Alzheimer disease and other dementias, neoplasms, vascular disease, inflammatory processes, or developmental abnormalities. The neuropathologic diagnosis thus plays an important role in patient care. Postmortem diagnosis may be important for families at risk of many disorders which have been shown to have a genetic basis.

Neuropathologists are also frequently consulted on issues of causation in legal actions involving Central Nervous System hemorrhage, trauma, infection, loss of consciousness, neoplasia, and toxicity. Faculty members Roger McLendon, MD, Christine Hulette, MD, Thomas Cummings, MDAnne Buckley, MD PhD and Shih-Hsiu "Jerry" Wang, MD PhD have active consultation services.

Because of their intimate knowledge of the brain, spinal cord, and peripheral nervous system in health and disease as well as their training in general anatomic pathology, neuropathologists often are involved in collaborations with the pharmaceutical industry in both pre-clinical and human drug trials. Neuropathologists play an essential role at Academic Medical Centers where they support their clinical and research colleagues in Neurosurgery, Neurology and Neuroradiology.

Consults

  • For nerve and muscle please follow special protocol (below)
  • Send completed clinical information form with case
  • Please call our office at 919-684-2533 with any questions

 

Teaching

The division of Neuropathology at Duke Medical Center has a long tradition of excellence in diagnostic and experimental pathology. Beginning in 1962 under the leadership of Dr. F. Stephen Vogel, this division has produced many leaders in Neuropathology and continues today with Dr. Roger McLendon (Director), Dr. Thomas CummingsDr. Christine Hulette, Dr. Anne Buckley and Shih-Hsiu "Jerry" Wang, MD PhD . Our division emphasizes a close collaborative relationship with the Duke divisions of Neuro-Oncology, Neurosurgery, Neurology, and Neuroradiology, a relationship best exemplified in the most recently published Seventh Edition of Russell and Rubinstein's Pathology of Tumors of the Nervous System, jointly edited by Duke's Darell Bigner and Roger McLendon along with Memorial Sloan-Kettering's Marc K. Rosenblum. Each year our service examines greater than 250 autopsy brains, 60 nerve biopsies, 50 muscle biopsies, and 450 neurosurgical cases, in addition to 350 consultations (predominately involving tumors of the central nervous system). This experience is heavily drawn on in the diagnostic atlas, Pathology of Tumors of the Central Nervous System. Furthermore, our program maintains highly productive experimental neuropathology programs in neuro-oncology (Drs. Thomas Cummings, and Roger McLendon) and neurotoxicology/neurodegenerative diseases (Dr. Christine Hulette). Neurodegenerative disease is mentored by Christine Hulette, M.D. Duke is recognized by the American Board of Pathology. Graduates of the training program play major roles in academic medical centers across the United States. Most of our trainees are members of American Association of Neuropathologists.

Our mission can be summarized as, "We seek in order to teach"; our training program in Neuropathology seeks to prepare independent investigators who can compete successfully for NIH grant support as well as provide excellent diagnostic service and teaching.

Neuropathology Educational Resources

Research 

Roger McLendon, MD is Professor of Pathology and Chief of Neuropathology, and a member of the Preston Robert Tisch Brain Tumor Center.  He investigates the role of molecular expression in brain tumor classification, diagnosis and therapeutic response. He is also the Director of the Preston Robert Tisch Brain Tumor Center - Brain Tumor Biorepository.

Christine Hulette, MD, Professor of Pathology, maintains a long term diagnostic interest in neurodegenerative disease. She is responsible for undergraduate medical education in Pathology at Duke School of Medicine and is actively involved in medical education research.

Thomas J. Cummings, MD, Professor of Pathology, and Professor of Ophthalmology, has active clinical and research interests in the following areas: Ophthalmic pathology (eye tumors, pathology of the optic nerve); neuropathology (brain tumors, neural tube defects, peripheral nerve and skeletal muscle pathology); orthopaedic pathology (bone and soft tissue tumors); leprosy involvement of the eye, peripheral nerve, bone, and soft tissues; and, general surgical pathology.

Anne F. Buckley, MD PhD, Assistant Professor of Pathology, is a member of the Preston Robert Tisch Brain Tumor Center, and conducts basic research on brain tumors and brain development in collaboration with Dr. Chay Kuo in the Department of Cell Biology.  Dr. Buckley is involved with translational and basic research on muscle and renal disorders with other research groups at Duke. She is head of the Muscle Pathology Service, and in addition to muscle pathology, her clinical practice includes general neuropathology and medical renal pathology. Dr. Buckley is also Medical Director of the Clinical Electron Microscopy Laboratory.

Faculty

Roger McLendon, MD

Chief

M216 Davison Bldg, Erwin Road

Durham, NC 27710

Office: 919-684-6940

Fax: 919-681-7634

Email

Christine M. Hulette, MD

Christine M. Hulette, MD

M217 Davison Bldg, Erwin Road

Durham, NC 27710

Office: 919-684-3994

Fax: 919-684-3670

Email

Anne F. Buckley, MD, PhD

Anne F. Buckley, MD, PhD

M215 Davison Bldg, Erwin Road

Durham, NC 27710

Office: 919-684-2533

Fax: 919-681-7634

Email

Shih-Hsiu "Jerry" Wang, MD PhD

Shih-Hsiu "Jerry" Wang, MD PhD

DUMC 3712

Durham NC 27710

919-681-6628

Email