Giselle
Yvette
López

Associate Professor in Pathology
Assistant Professor in Neurosurgery
Member of the Duke Cancer Institute
Addresses
- 207M Green Zone, Duke South, DUMC Box 3712, Durham, NC 27710
- Box 3712 Med Ctr, Durham, NC 27710
Overview
I am a physician scientist with a clinical focus on neuropathology, and a research interest in brain tumors. Originally from Maryland, I completed my undergraduate training at the University of Maryland, completing degrees in Physiology and Neurobiology as well as Spanish Language and Literature. I subsequently came to Duke for my MD and PhD, and discovered a passion for brain tumor research, and quickly realized that this was my life's calling. Clinically, I specialize in neuropathology. While I have active projects and collaborations on many kinds of brain tumors, my lab's primary focus is oligodendroglioma, a kind of infiltrative brain tumor that impacts adults. Our goal is to identify new ways to treat these tumors and improve the lives of patients with oligodendrogliomas and other kinds of brain tumors. By blending together computational approaches with wet lab approaches, we use the strengths inherent in different research modalities to excel in identifying unexplored pathways and thinking outside the box to identify new ways to target this brain tumor. We do this through research in an inclusive, multidisciplinary lab environment that strives for excellence in research while creating well-rounded, thriving scientists ready for the next step in their careers.
Research Opportunities
We currently have opportunities in the laboratory for one-year projects (ideal for post-bac fellows or third year med student research experiences). These projects are centered on identifying and testing novel therapeutic approaches for oligodendroglioma using in vitro and in vivo model systems. Please reach out if you are interested and would like to hear more about my mentoring philosophy, lab culture, and opportunities to be at the cutting edge of science.
Research Opportunities
We currently have opportunities in the laboratory for one-year projects (ideal for post-bac fellows or third year med student research experiences). These projects are centered on identifying and testing novel therapeutic approaches for oligodendroglioma using in vitro and in vivo model systems. Please reach out if you are interested and would like to hear more about my mentoring philosophy, lab culture, and opportunities to be at the cutting edge of science.
Education
- Fellowship, NEUROPATHOLOGY - University of California, San Francisco
- Residency, ANATOMIC PATHOLOGY - University of California, San Francisco
- Certificate, CELL AND MOLECULAR BIOLOGY - Duke University
- MD./PhD. 2014 - Duke University, School of Medicine
- B.A. 2005 - University of Maryland, College Park
- B.S. 2005 - University of Maryland, College Park
Grants
- Innate Antiviral Signals for Cancer Immunotherapy awarded by National Institute of Neurological Disorders and Stroke 2018 - 2028
- Duke Preparing Research Scholars in Biomedical Sciences- Post-Baccalaureate Research Education Program awarded by National Institute of General Medical Sciences 2022 - 2027
- Medical Scientist Training Program awarded by National Institute of General Medical Sciences 2022 - 2027
- Genomic and Spatial Expression Analysis of Oligodendroglioma to Identify Novel Therapeutic and Prognostic Targets awarded by Doris Duke Charitable Foundation, Inc. 2022 - 2025
- Duke CTSA (KL2) awarded by National Institutes of Health 2018 - 2024
Publications
- Khasraw, Mustafa, Kirit Singh, Matthew Foster, Marlene Violette, Anna Corcoran, Kelly Hotchkiss, Chelsea Railton, et al. “A surgical window of opportunity trial evaluating the effect of the PCSK9 inhibitor evolocumab on tumoral MHC-I expression and CD8+ infiltration in glioma.” Springer Science and Business Media LLC, January 22, 2025. https://doi.org/10.21203/rs.3.rs-5822396/v1.
- Tripathi, Shashwat, Hinda Najem, Corey Dussold, Sebastian Pacheco, Ruochen Du, Moloud Sooreshjani, Lisa Hurley, et al. “Pediatric glioma immune profiling identifies TIM3 as a therapeutic target in BRAF fusion pilocytic astrocytoma.” J Clin Invest 134, no. 19 (August 13, 2024). https://doi.org/10.1172/JCI177413.
- Liu, Mengyi, Zhicheng Ji, Vaibhav Jain, Vanessa L. Smith, Emily Hocke, Anoop P. Patel, Roger E. McLendon, David M. Ashley, Simon G. Gregory, and Giselle Y. López. “Spatial transcriptomics reveals segregation of tumor cell states in glioblastoma and marked immunosuppression within the perinecrotic niche.” Acta Neuropathol Commun 12, no. 1 (April 22, 2024): 64. https://doi.org/10.1186/s40478-024-01769-0.
- Yang, Yuanfan, Michael C. Brown, Gao Zhang, Kevin Stevenson, Malte Mohme, Reb Kornahrens, Darell D. Bigner, David M. Ashley, Giselle Y. López, and Matthias Gromeier. “Polio virotherapy targets the malignant glioma myeloid infiltrate with diffuse microglia activation engulfing the CNS.” Neuro Oncol 25, no. 9 (September 5, 2023): 1631–43. https://doi.org/10.1093/neuonc/noad052.
- Regal, Joshua A., María E. Guerra García, Vaibhav Jain, Vidyalakshmi Chandramohan, David M. Ashley, Simon G. Gregory, Eric M. Thompson, Giselle Y. López, and Zachary J. Reitman. “Ganglioglioma deep transcriptomics reveals primitive neuroectoderm neural precursor-like population.” Acta Neuropathol Commun 11, no. 1 (March 25, 2023): 50. https://doi.org/10.1186/s40478-023-01548-3.
- Cimino, Patrick J., Courtney Ketchum, Rust Turakulov, Omkar Singh, Zied Abdullaev, Caterina Giannini, Peter Pytel, et al. “Expanded analysis of high-grade astrocytoma with piloid features identifies an epigenetically and clinically distinct subtype associated with neurofibromatosis type 1.” Acta Neuropathol 145, no. 1 (January 2023): 71–82. https://doi.org/10.1007/s00401-022-02513-5.
- Smith, Vanessa, Annick Desjardins, Julieann Lee, Patrick Devine, Calixto-Hope Lucas, Ranleigh Fleshman, Arie Perry, and Giselle Lopez. “Cerebellar Collision Tumor of High-Grade Astrocytoma and Meningioma.” In JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 81:451–451, 2022.
- Santana-Santini, Jorge, Huifang Dai, Paul Ferrell, Salvatore Pizzo, and Giselle Lopez. “Anti-GRP78 for the treatment of metastatic brain tumors.” In JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 81:490–490, 2022.
- Cimino, Patrick, Courtney Ketchum, Zied Abdullaev, Rust Turakulov, Caterina Giannini, Peter Pytel, Giselle Lopez, et al. “Expanded Analysis of High-Grade Astrocytoma with Piloid Features Identifies Epigenetically Distinct Subtypes.” In JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 81:440–440, 2022.
- Ahn, Janice S., John Ervin, Thomas J. Cummings, Giselle Y. López, and Shih-Hsiu J. Wang. “Papillary Glioneuronal Tumor With a Novel GPR37L1-PRKCA Fusion.” J Neuropathol Exp Neurol 80, no. 10 (October 26, 2021): 1004–6. https://doi.org/10.1093/jnen/nlab055.
Past Appointments
- Assistant Professor in Pathology
- Assistant Professor in Neurosurgery
- Assistant Professor in Pathology
Academic Positions
- Clinical Research Fellow, University of California, San Francisco
- Clinical Instructor, University of California, San Francisco
Professional Activities
- Role of Pathologists in Big Data Studies. Pathobiology of Disease Lecture Series. University of Chicago. February 13, 2025
- My Journey through Science. Cancer Career Exploration Day. Duke Cancer Institute. September 21, 2024
- Member. Response Assessment in Neuro-Oncology (RANO) Pathology Working Group. 2024 - 2025
- Member. Diversity, Equity and Inclusion Committee. American Society for Clinical Pathology. 2024 - 2025
- Medical Scientist Training Program. Steering Committee. Steering Committee. 2024 - 2025
- Neuropathology. Pathology Update. American Society for Clinical Pathology. Nashville, TN. November, 2023
- Biomarkers and Targets for Oligodendroglioma. 25th Anniversary Event: “From Legacy to Future". Doris Duke Foundation. October, 2023
- The critical role of the pathologist in emerging multi-omic scientific approaches. 10th Annual RTP Rodent Pathology Symposium. Research Triangle Park Veterinary Pathologists. NC State University. September, 2023
- Neuropathology. Pathology Update. American Society for Clinical Pathology. Chicago, IL. June, 2023
- Member. Neuro-Oncology Biospecimen Working Group. Society for Neuro-Oncology. 2023 - 2025
Newsfeeds
- Dr. Giselle López Invited to Present on the Role of Pathologists in Big Data Studies
- Dr. Giselle López Accepted to SNO Future Leaders Development Program
- Dr. López Receives Spark Award from AWIS
- Two Faculty Members Named to ASCP 40 Under 40 List
- Dr. López Leads Neuropathology Sections of ASCP Pathology Update
- Dr. López Receives Funding from Duke Fund to Retain Clinical Scientists
- Dr. López Finds Community in Pathology
- Dr. López receives Clinical Scientist Development Award
- Pathilton!
Courses
- NEUROSUR 404C: Neuro-Oncology
Licenses
- 2018-01474. North Carolina. 2018
Associate Professor in Pathology
207M Green Zone, Duke South, DUMC Box 3712, Durham, NC 27710
Mailing address
Box 3712 Med Ctr, Durham, NC 27710