Hematopathology

The Hematopathology division provides specialized diagnostic consultations in malignant and non-malignant disorders of blood, bone marrow, and lymphoid organs. Division faculty have strong expertise in the diagnosis of leukemia and lymphoma in adults and children and review over 2000 in-house cases and nearly 1000 consult cases every year. A comprehensive approach to diagnosis integrates standard histologic and cytologic findings with results from specialty laboratories at Duke, including Flow Cytometry, Molecular Diagnostics, Cytogenetics, Hematology, Immunopathology, and Image Analysis laboratories. Crucial prognostic information is available through these state-of-the-art tests, providing vital support for the selection of the correct treatment regimen. The Hematopathology diagnostic unit is located in the Hematology/Oncology Clinic in Duke Cancer Center, facilitating clinical consultations with the treating physicians.

The division accepts prepared slides, processed tissue and fresh specimens for diagnostic consultation and additional testing as appropriate. For information regarding submission of specimens for consultations or second opinion please contact the Hematopathology Secretary by calling 919-684-2486 (Fax to 919-684-1856) or write to us addressed to DUMC 3712, Durham, NC 27710, USA.

 Acute Myeloid Leukemia
Bone Marrow: Acute Myeloid Leukemia
   Hodgkin Lymphoma
Lymph Node: Hodgkin Lymphoma
     
 “MALT” Lymphoma
Stomach: “MALT” Lymphoma
   Adult T-cell Leukemia
Peripheral Blood : Adult T-cell Leukemia
     
  Flow cytometry-   Minimum Residual Disease Detection  in treated Multiple Myeloma (0.082% abnormal plasma cells)     Flow cytometry-   Minimum Residual Disease Detection  in treated Multiple Myeloma (0.082% abnormal plasma cells)
Bone Marrow:  Flow cytometry-  
Minimum Residual Disease Detection  in treated Multiple Myeloma
(0.082% abnormal plasma cells)

Faculty

Anand S. Lagoo, MD, PhD Chief   As a diagnostic hematopathologist, my clinical interests are primarily focused on hemato-lymphoid malignancies  (leukemia, lymphoma, Hodgkin disease, multiple myeloma, and others).  These diagnostic interpretations are based on careful synthesis of findings from morphological examination of blood, bone marrow and lymphoid tissue coupled with a plethora of ancillary studies including flow cytometry, immunohistochemistry, cytogenetics and molecular diagnostics. As medical director of the Clinical Flow Cytometry laboratory, I oversee the accuracy of these high complexity diagnostic tests and am engaged in the development and validation of new tests crucial in continued care of the patients with leukemia, lymphoma, and myeloma. My translational research interests include the study of pathological changes following non-conventional treatments for myeloid, lymphoid, and plasma cell neoplasms and evaluating the spectrum of lymphoid tissue involvement by plasmacytic / plasmacytoid cells.

Jadee Neff, MD, PhD.    The majority of my time is devoted to microscopically examining tissue and bone marrow biopsies to diagnose hematologic malignancies (leukemia, lymphoma, myeloma, etc.) and testing patients’ DNA (from tumors or from blood) to detect actionable somatic or inherited mutations.  I strive for excellence in my clinical work by providing accurate diagnoses as rapidly and cost-efficiently as possible.  My research interests involve  1) understanding the biology of chronic leukemias/lymphomas of cytotoxic lymphocytes and  2) exploring the immunomodulatory response to neoplastic disease and developing methods to monitor and thereby refine tumor immunotherapy.

Endi Wang, MD, PhD.    As a diagnostic pathologist, I focus the diagnostic activities on hematopoietic diseases, particularly hematolymphoid neoplasms (leukemia, lymphoma, etc.).  In addition, I conduct clinical-related research, which consists primarily of case studies and case series investigations. My primary scholarly interests include therapy, immune status or other intrinsic or environmental factors as causes for hematopoietic neoplasms, and genetic analysis of neoplastic evolution in leukemia/lymphoma.  Refer to the published works since 2004.

 

Anand S. Lagoo, MD, PhD, Chad M. McCall, MD PhD, Endi Wang, MD, PhD, Jadee Neff, MD, PhD,
Faculty
Anand S. Lagoo, MD, PhD

Anand S. Lagoo, MD, PhD

Chief

DUMC 3712

Durham, NC 27710

Office: 919-668-0921

Fax: 919-684-1856

Email

Chad M. McCall, MD PhD

Chad M. McCall, MD PhD

DUMC 3712

Durham, NC 27710

Office: 919-684-2429

Fax: 919-684-1856

Email

Jadee Neff, MD PhD

Jadee Neff, MD PhD

DUMC 3712

Durham, NC 27710

Office: 919-681-9894

Email

Endi Wang, MD, PhD

Endi Wang, MD, PhD

DUMC 3712

Durham, NC 27710

Office: 919-684-2486

Fax: 919-684-1856

Email