Johnston-West Endowed Chair of Pathology Jiaoti Huang, MD, PhD, was invited to deliver the keynote Distinguished American Urological Association (AUA) Lecture at the 2025 Annual Meeting of the Society for Basic Urologic Research (SBUR) from Nov. 13-16, 2025, in Orlando, Fla.
In his presentation, “Castration Resistance of Prostate Cancer: Cellular Mechanisms and Novel Therapy,” Huang shared insights from two decades of his lab’s research into why some prostate cancers stop responding to standard hormone treatments. This stage is known as castration-resistant prostate cancer, and this form of the disease is particularly challenging because it continues to grow even in the presence of therapies that lower testosterone, which most prostate cancers depend on. His work focuses on a rare and aggressive form involving neuroendocrine tumor cells.
He also described multiple new biomarkers and treatment targets discovered by his lab, along with innovative strategies to attack these molecules. These breakthroughs could lead to more effective therapies for patients with advanced prostate cancer.