Qianben Wang
Primary Investigator
Professor of Pathology
Member of the Duke Cancer Institute
Location
Room 1027A, GSRB1, Box 103864, 905 LaSalle St., Durham, NC, 27710

Research Interests

My laboratory is primarily interested in understanding the epigenetic mechanisms driving progression of hormone-dependent cancers. One key area of our research is studying the genomic function of androgen receptor (AR) in prostate cancer. AR is a ligand-dependent transcription factor belonging to the nuclear hormone receptor (NR) superfamily. Recently, we have utilized high-throughput techniques such as ChIP-exo (chromatin immunoprecipitation-exonuclease combined with high-throughput sequencing) and ChIP-seq (ChIP combined with high-throughput sequencing) to globally identify AR-bound genomic sites and precisely define AR binding motifs leading to target gene expression, cancer progression and treatment resistance.

We are expanding our focus from transcriptional regulation by AR alone to include a wider view of global transcriptional regulation in prostate cancer. These efforts have included studies of transcription factor-centered, multi-layer transcription regulatory networks in prostate cancer, which involve transcription factors (e.g. AR, FOXA1, GATA2 and CREB1), transcription coactivators (e.g. Mediator and histone acetyltransferases), and epigenetic regulators (e.g. histone modifications, chromatin looping and nucleosome positioning). These efforts are leading to many exciting results that will inform the development of more effective options for prostate cancer, as existing treatments predominantly target AR itself.

Our recent studies are designed to target transcriptional and epigenetic mechanisms discovered from the omics studies by integrating CRISPR technologies and nanotechnology.

Click here for the Qianben Wang Lab website.

Publications

Please see a complete list of published works at PubMed.

Publications:

Academic Articles