Research Interests
The Park laboratory is interested in:
1. Understanding prostate cancer progression using our novel human epithelial cell transformation system.
2. Investigating the pathogenesis of prostate and other epithelial cancers using primary human cells with organoid culture, which will create novel pre-clinical disease models.
3. Identifying vulnerabilities in treatment-resistant epithelial cancers.
4. Developing novel therapies targeting oncogenic drivers and other disease vulnerabilities.
The Lab Team
Publications
Please see Pub Med for current listings.
Research Focus
Using our unique human cell transformation system, we are trying to:
- Understand human cancer initiation, progression and evolution
- Investigate the pathogenesis of prostate and other epithelial cancers
- Identify oncogenic drivers for targeted therapy.
Reprogramming normal human cells into cancer cells by recurrent genetic alterations found in human cancers (Science 2018)
Convergence of transcriptional and epigenetic landscapes in two different cancer types (Science 2018 and Cancer Cell 2019)
A novel genetically engineered small cell bladder cancer model reveals potential therapeutic targets (PNAS 2020)
