The Hale laboratory employs techniques of cellular and molecular biology to study mechanisms responsible for the generation of both normal immune responses and immune-mediated diseases. Research in the laboratory is mainly focused on inflammatory bowel disease (IBD), an immune-mediated disorder that is hypothesized to result from the abnormal immune response of a genetically susceptible host to the antigens derived from enteric bacteria. Development of optimal treatments for disease requires a detailed understanding of mechanisms of disease pathogenesis. Thus current work in the laboratory is aimed at understanding triggers of intestinal inflammation and mechanisms of inflammation-associated neoplasia in addition to developing novel therapies for IBD treatment. Ongoing research also includes investigating mechanisms that determine the immunogenicity of oral antigens, to develop novel adjuvants for oral vaccines. This work has relevance for pathogenesis and treatment of infectious diseases affecting the gastrointestinal tract, as well as for inflammatory bowel disease.
Dr. Hale is an expert in pathologic evaluation of colitis and immunodeficiency in both humans and mice and is board-certified in Anatomic and Clinical Pathology.
Please see Pub Med for current listings.
- Hammer, G, Liang, J, Huang, H-I, Benzatti, F, Karlsson, A, and Hale, LP. "Microbiota upregulate distinct APC functions in each intestinal dendritic cell subset, in a Myd88-independent fashion." May 1, 2016
- Pham, TTN, Burchette, JL, and Hale, LP. "Fatal disseminated adenovirus infections in immunocompromised patients." October 2003
- Hale, LP. "Thymic microenvironment abnormalities in X-linked severe combined immunodeficiency syndrome." October 2002
- Ito, R, Hale, LP, Geyer, SM, Li, J, Sornborger, A, Kajimura, J, Kusunoki, Y, Yoshida, K, van den Brink, MRM, Kyoizumi, S, Manley, NR, Nakachi, K, and Sempowski, GD. "Late Effects of Exposure to Ionizing Radiation and Age on Human Thymus Morphology and Function." Radiation research 187, no. 5 (May 2017): 589-598
- Liang, J, Huang, H-I, Benzatti, FP, Karlsson, AB, Zhang, JJ, Youssef, N, Ma, A, Hale, LP, and Hammer, GE. "Inflammatory Th1 and Th17 in the Intestine Are Each Driven by Functionally Specialized Dendritic Cells with Distinct Requirements for MyD88." Cell reports 17, no. 5 (October 2016): 1330-1343
- Hale, LP, Kant, EP, Greer, PK, and Foster, WM. "Retraction: Iron Supplementation Decreases Severity of Allergic Inflammation in Murine Lung." PLOS ONE 11, no. 5 (May 9, 2016): e0155387-e0155387
- Kajimura, J, Ito, R, Manley, NR, and Hale, LP. "Optimization of Single- and Dual-Color Immunofluorescence Protocols for Formalin-Fixed, Paraffin-Embedded Archival Tissues." The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 64, no. 2 (February 2016): 112-124
- Hart, BE, Hale, LP, and Lee, S. "Immunogenicity and protection conferred by a recombinant Mycobacterium marinum vaccine against Buruli ulcer." Trials in Vaccinology 5 (2016): 88-91
- Nagy, E, Rodriguiz, RM, Wetsel, WC, MacIver, NJ, and Hale, LP. "Reproduction and Growth in a Murine Model of Early Life-Onset Inflammatory Bowel Disease." PloS one 11, no. 4 (January 2016): e0152764-
- Hart, BE, Hale, LP, and Lee, S. "Recombinant BCG Expressing Mycobacterium ulcerans Ag85A Imparts Enhanced Protection against Experimental Buruli ulcer." PLoS neglected tropical diseases 9, no. 9 (September 22, 2015): e0004046-
- Gerriets, VA, Kishton, RJ, Nichols, AG, Macintyre, AN, Inoue, M, Ilkayeva, O, Winter, PS, Liu, X, Priyadharshini, B, Slawinska, ME, Haeberli, L, Huck, C, Turka, LA, Wood, KC, Hale, LP, Smith, PA, Schneider, MA, MacIver, NJ, Locasale, JW, Newgard, CB, Shinohara, ML, and Rathmell, JC. "Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation." The Journal of clinical investigation 125, no. 1 (January 2015): 194-207
- Macintyre, AN, Gerriets, VA, Nichols, AG, Michalek, RD, Rudolph, MC, Deoliveira, D, Anderson, SM, Abel, ED, Chen, BJ, Hale, LP, and Rathmell, JC. "The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function." Cell metabolism 20, no. 1 (July 2014): 61-72
- Haynes, BF, Hale, LP, Weinhold, KJ, Patel, DD, Liao, HX, Bressler, PB, Jones, DM, Demarest, JF, Gebhard-Mitchell, K, Haase, AT, and Bartlett, JA. "Analysis of the adult thymus in reconstitution of T lymphocytes in HIV-1 infection." J Clin Invest 103, no. 6 (March 15, 1999): 921-
- Haynes, BF, Hale, LP, Weinhold, KJ, Patel, DD, Liao, H-X, Bressler, PB, Jones, DM, Demarest, JF, Gebhard-Mitchell, K, Haase, AT, and Bartlett, JA. "Erratum: Analysis of the adult thymus in reconstitution of T lymphocytes in HIV-1 infection (The Journal of Clinical Investigation (1999) 103 (453- 460))." Journal of Clinical Investigation 103, no. 6 (1999): 921--