Discoveries about the mechanisms of bladder infections are discussed in this article by Sarah Avery in Duke Health News, and the paper is published in Nature Immunology. Authors from the Abraham Lab include Pathology PhD student Byron Hayes.
DURHAM, N.C. – As many people know, bladder infections can be a painful and recurring condition, and those who are prone to the infections often report they have to “go” with greater frequency and urgency.
These two related conditions are caused by an aberrant immune response that prioritizes repairing tissue in the bladder wall over clearing the bacteria, according to a new study led by Duke Health researchers.
The researchers said the findings, publishing online May 18 in the journal Nature Immunology, improve the possibility of identifying more effective ways to treat urinary tract infections, or UTIs, which are especially common among women.
and in Nature Immunology: "A highly polarized TH2 bladder response to infection promotes epithelial repair at the expense of preventing new infections."