Pathology Grand Rounds - Deciphering Drivers of and Developing Immunotherapies Against Genitourinary Cancers

At the conclusion of this activity, learners should be able to: * Discuss molecular mechanisms of transdifferentiation from prostate adenocarcinoma to neuroendocrine prostate cancer * Discuss biochemical recurrence of prostate cancer and the catch bond engineering of T cell receptors targeting prostatic acid phosphatase (PAP) for therapeutic intervention * Discuss available treatments for high-risk non-muscle invasive bladder cancer and the development of a novel chimeric antigen receptor T cell therapy targeting Nectin-4 that is administered via intravesical instillation