Everitt Lab

Everitt Lab

Animal Pathology Core

Jeffrey Everitt, DVM

Professor Track - V in Pathology

Research Interests

The focus of Dr. Everitt’s laboratory is to provide research pathology support for the development and characterization of animal models for translational research. The laboratory works with a variety of other shared resources in the School of Medicine to provide collaborative and supporting services for Duke biomedical community projects that have macroscopic pathology, histopathology or clinical pathology needs in research animal models. Dr. Everitt is available for consultation and collaboration on the following:

Animal necropsy support
Phenotyping of genetically modified rodents
Preclinical toxicology studies
Project consultation during initial study design, execution, analysis, and publication preparation
Morphologic diagnoses using standardized consensus nomenclature
Standardized scoring systems for neoplastic, inflammatory, and other non-neoplastic lesions
Cause of death assignments, co-morbidity, and disease burden quantification
Customized methods development for project-specific pathology objectives
Comparison and validation of animal models to human conditions

Publications

Please see Pub Med for current listings

Hu, F, Martin, H, Martinez, A, Everitt, J, Erkanli, A, Lee, WT, Dewhirst, M, and Ramanujam, N. "Distinct Angiogenic Changes during Carcinogenesis Defined by Novel Label-Free Dark-Field Imaging in a Hamster Cheek Pouch Model." Cancer research 77, no. 24 (December 2017): 7109-7119
Kim, Y, Lee, H-M, Xiong, Y, Sciaky, N, Hulbert, SW, Cao, X, Everitt, JI, Jin, J, Roth, BL, and Jiang, Y-H. "Targeting the histone methyltransferase G9a activates imprinted genes and improves survival of a mouse model of Prader-Willi syndrome." Nature medicine 23, no. 2 (February 2017): 213-222
Bradley, T, Yang, G, Ilkayeva, O, Holl, TM, Zhang, R, Zhang, J, Santra, S, Fox, CB, Reed, SG, Parks, R, Bowman, CM, Bouton-Verville, H, Sutherland, LL, Scearce, RM, Vandergrift, N, Kepler, TB, Moody, MA, Liao, H-X, Alam, SM, McLendon, R, Everitt, JI, Newgard, CB, Verkoczy, L, Kelsoe, G, and Haynes, BF. "HIV-1 Envelope Mimicry of Host Enzyme Kynureninase Does Not Disrupt Tryptophan Metabolism." Journal of immunology (Baltimore, Md. : 1950) 197, no. 12 (December 2016): 4663-4673
Brønstad, A, Newcomer, CE, Decelle, T, Everitt, JI, Guillen, J, and Laber, K. "Current concepts of Harm-Benefit Analysis of Animal Experiments - Report from the AALAS-FELASA Working Group on Harm-Benefit Analysis - Part 1." Laboratory animals 50, no. 1 Suppl (June 2016): 1-20
Laber, K, Newcomer, CE, Decelle, T, Everitt, JI, Guillen, J, and Brønstad, A. "Recommendations for Addressing Harm-Benefit Analysis and Implementation in Ethical Evaluation - Report from the AALAS-FELASA Working Group on Harm-Benefit Analysis - Part 2." Laboratory animals 50, no. 1 Suppl (June 2016): 21-42
Scudamore, CL, Soilleux, EJ, Karp, NA, Smith, K, Poulsom, R, Herrington, CS, Day, MJ, Brayton, CF, Bolon, B, Whitelaw, B, White, ES, Everitt, JI, and Arends, MJ. "Recommendations for minimum information for publication of experimental pathology data: MINPEPA guidelines." The Journal of pathology 238, no. 2 (January 2016): 359-367
Shen, Z, Feng, Y, Sheh, A, Everitt, J, Bertram, F, Paster, BJ, and Fox, JG. "Isolation and characterization of a novel Helicobacter species, Helicobacter jaachi sp. nov., from common marmosets (Callithrix jaachus)." Journal of medical microbiology 64, no. 9 (September 2015): 1063-1073
Everitt, JI. "The future of preclinical animal models in pharmaceutical discovery and development: a need to bring in cerebro to the in vivo discussions." Toxicologic pathology 43, no. 1 (January 2015): 70-77
Rose, M, Everitt, J, Hedrich, H, Schofield, J, Dennis, M, Scott, E, Griffin, G, and ICLAS Working Group on Harmonization,. "ICLAS Working Group on Harmonization: international guidance concerning the production care and use of genetically-altered animals." Laboratory animals 47, no. 3 (July 2013): 146-15

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Everitt Lab

Everitt Lab

Jeffrey Everitt, DVM

Research Interests

Publications

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