Huang Receives Synergistic Idea Award

Dr. Jiaoti Huang has been awarded a new Synergistic Idea Award by the Department of Defense Prostate Cancer Research Program. The project is entitled “Novel Tumor Suppressive Role of Phosphodiesterases in Prostate Cancer”. The application proposes to test the hypothesis that phosphodiesterases (PDEs) exhibit tumor-suppressive functions as negative regulators of prostate cancer–relevant oncogenic signaling pathways. The project’s specific aims are to (1) define the mechanistic basis for PDE expression loss and characterize the molecular and cellular phenotypic changes occurring upon PDE loss, (2) utilize genetically engineered mouse models (GEMMs) of prostate carcinogenesis to explore the temporal tumor-suppressive function of PDEs in vivo, and (3) translate the findings to human prostate cancer, correlating the expression of PDEs and their downstream targets with clinical outcomes in large patient cohorts with extensive follow-up information.

The other PIs of the Synergistic Award are Drs. Qianben Wang and Steven Clinton of Ohio State University.