Hankey Selected in NIH T32 Post-Doc Training Program

William Hankey, PhD

William Hankey, PhD, a postdoctoral associate in the laboratory of Dr. Qianben Wang, has been awarded the opportunity to participate in the Post-Doctoral Training Program in Genomic Medicine.  This two-year training program is organized through the Duke Center for Applied Genomics and Precision Medicine, under the direction of Drs. Geoffrey Ginsburg and Susanne Haga, and is supported by a T32 Ruth L. Kirschstein Institutional National Research Service Award.  The research project is entitled “Potential roles of PDE5A inhibition in prostate cancer incidence and recurrence”, and will characterize the responses of normal and malignant prostate cells to pharmacological inhibition of the PDE5A enzyme (for the treatment of erectile dysfunction and other conditions).  The project will determine the phenotypes of PDE5A inhibition in prostate cancer, perform transcriptional and proteomic profiling to identify potential effector molecules downstream of PDE5A, and translate key findings into a human disease model using histopathological staining of patient tissues.  The broader goal of the project is to confirm the safety of PDE5A inhibition in patient populations susceptible to prostate cancer incidence or recurrence and to identify pathways that mediate undesirable off-target effects.